And of thy sons that shall issue from thee, which thou shalt beget, shall they take away,.... Manasseh his immediate son was taken and carried to Babylon, though afterwards released; nor does it appear that he was made a eunuch or an officer there; this had its fulfilment in Jeconiah and his children, and in others that were of the seed royal, as Daniel, Hananiah, Mishael, and Azariah, to whom the Jewish commentators apply this; this is expressed in different words, signifying much the same, to affect the mind of Hezekiah the more:and they shall be eunuchs in the palace of the king of Babylon; or "chamberlains"; and who very often were castrated for that purpose, though it does not necessarily signify such, being used of officers in general.
The Targum renders it "princes" ; and such an one was Daniel in the court of the king of Babylon; and his three companions were also promoted, Da 2:48.