Let his children be fatherless, and his wife a widow. This sometimes is the case of good men, who leave widows and fatherless children, whom the Lord shows mercy to; being the Father of the fatherless, and the Judge of the widow, Ps 68:5, but sometimes it is threatened and comes as a judgment, when the Lord shows no mercy and favour to them, Ex 22:24.
And this is the case here, which very probably was literally fulfilled in Judas, who might have a wife and children; since it looks as if the other apostles had, and certain it is that one of them had a wife, even Peter, in the times of Christ; see 1Co 9:5.
And this was verified in the people of the Jews; whom the Lord divorced from himself, and wrote a "loammi" upon them, and left them as orphans and fatherless, Ho 1:9.