And I will tread down the people in mine anger,....See Gill on "Isa 63:3",and make them drunk in my fury; or with it the wrath of God is signified by a cup, which he gives wicked men to drink, and which is an inebriating one to them, Ps 75:8, and here it signifies the cup of the wine of the fierceness of God's wrath, which shall be given to mystical Babylon, to antichrist and his followers, Re 14:10:and I will bring down their strength to the earth; their strong kingdoms, fortified cities, and mighty men, their wealth and riches, of which they boasted, and in which they trusted; see Isa 26:5.
The eighteenth chapter of the Revelation is a commentary on these words.