Deliver me, O my God, out of the hand of the wicked,.... Meaning Absalom his son, as Arama, who had risen up in rebellion against him; and he may not only intend him, but all those wicked men that had joined with him: it was David's mercy he had a covenant God to go to, and could claim his interest in him, who had power to deliver him, and from whom he might expect it;out of the hand of the unrighteous and cruel man; or "leavened" ; a sour ill natured man; one leavened with malice and wickedness: perhaps Ahithophel is intended.
It may be applied to any wicked, lawless, and tyrannical persecutor of God's people; and particularly to the lawless and wicked one, the man of sin, the son of perdition, antichrist, 2Th 2:4.