I am weary of my crying,.... In his distress; when, bearing the punishment both of loss and sense, he cried unto God; he prayed earnestly, with great intenseness and fervency of spirit; he offered supplications, with strong cryings and tears, insomuch that he calls it a roaring: and whereas there was a seeming delay of answer to his cries, he cried till he was weary of crying; and yet it is remarkable that his last cry was with a loud voice, which surprised the centurion; see Ps 22:1;my throat is dried; with crying, so that he was hoarse; or "burnt" ; with inward heat of a fever, which usually attended persons crucified; see Ps 22:15;mine eyes fail while I wait for my God; God the Father was the God of Christ, as he was man; he prepared a body for him, and anointed his human nature with the Holy Spirit; he supported and upheld him: and as such Christ loved him, believed in him, prayed to him, and waited and looked for help and salvation from him; this being delayed, his eyes failed with intense looking about for it, as well as with grief and tears.
Ainsworth observes, that failing of the eyes is one of the curses of the law, Le 26:16, and it shows how in every thing Christ was made a curse for his people.