and with some it has the signification of impudence and audaciousness, from the sense of the word in the Arabic language, see Isa 3:9; as if they behaved towards him in a very impudent manner: or, though they "knew" him, as the Targum paraphrases it, yet they were "not ashamed" to reproach him; though they knew that he was a man that feared God; they knew his character and conversation before his all afflictions came on, and yet traduced him as an hypocrite and a wicked man.
Whatever is sinful, men should be ashamed of, and will be sooner or later; not to be ashamed thereof is an argument of great hardness and impenitence; and among other things it becomes saints to be ashamed of their making themselves strange to one another.
Some render it interrogatively , "are ye not ashamed?" &c. you may well be ashamed, if you are not; this is put in order to make them ashamed. yl wrkht "indurastis facies vestras contra me", Vatablus; so Broughton.
"Erubescitis subsannare me", Pagninus. Drusius; so Schultens.