Thou renewest thy witnesses against me. Each fresh calamity that Job suffers is a new witness that God is displeased with him, both in his own eyes, and in those of his "comforters." Hie disease was no doubt continually progressing, and going from bad to worse, so that every day a new calamity seemed to befall him.
And increasest thine indignation upon me; i.e. "makest it more and more evidently to appear, that thou art angry with me." Changes and war are against me; rather, changes and a host; i.e. attacks that are continually changing—a whole host of them, or "host after host", come against me.