The command in this verse differs from that in Leviticus 19:3 by adding the injunction to reverence my sanctuary to that requiring the observance of the sabbath. It is a matter of experience that where the sabbath is not kept, God's sanctuary is not reverenced, and that that reverence increases or fails away according as the obligation of the sabbatical law, whether in its Jewish form or its Christian form, be more or less recognized.
The sabbatical ordinance is necessary as a previous condition of religious worship. Without it, the business and pleasure of the world are too strong to give way to the demands upon time made by the stated service of God.
The verse is repeated in Le Leviticus 26:2. "When the Lord's day is kept holy, and a holy reverence for the Lord's sanctuary lives in the heart, not only are many sins avoided, but social and domestic life is pervaded by the fear of God, and characterized by devoutness and propriety" (Keil).