And the fifth angel poured out his vial upon the seat of the beast,.... The beast is the same with that in Re 13:1 and which again shows that to be one and the same: the seat or throne of the beast is Rome, which, when the empire was Pagan, was the seat of Satan, or the dragon, Re 2:13 and when the beast or antichrist was risen, the dragon gave this seat, as well as his authority to him, Re 13:2 and is that city which is so often called, in this book, the great city, and is manifestly pointed out by its seven mountains, on which the city of Rome stood, Re 17:9 and the pouring out of this vial upon it denotes the destruction of it, when it will be burnt down, and become desolate, an habitation of devils, of every foul spirit, and hateful bird, Re 18:2 and this corresponds with the fifth trumpet; for as that brings in the rise of antichrist, both eastern and western, who rose much about the same time, so this vial affects him particularly; the western antichrist, his seat and kingdom.
Mr. Daubuz refers this plague to the expulsion of the western and eastern emperors from their capital cities, Rome and Constantinople, and to the mischiefs caused by the antipopes in the west, and to the quarrels and schism in the Greek churches in the fourteenth century.
And his kingdom was full of darkness; not only of the darkness of false doctrine and superstition, for so it was always, being filled with the smoke of the bottomless pit; nor only of judicial blindness and darkness, which the subjects of the antichristian state are given up unto; but rather of a discovery of all this, with all their hidden works of darkness, which will now be brought to light; though it seems chiefly to design the great affliction and distress the antichristian state will be in at this time, which darkness sometimes signifies; see Isa 9:1 it having lost its sun, the pope, under the preceding vial, and its seat, the city of Rome, under this: the sense is, that it will be greatly obscured in its glory and magnificence, in its traffic and riches, Re 18:11 its power and authority will be greatly diminished, and it will be had in contempt by the princes of the earth; though it will not as yet be utterly destroyed, for its utter destruction is reserved for the seventh and last vial.
The allusion is to the plague of darkness in Egypt, Ex 10:21.