And I will set my face against them,.... In wrath to destroy them; see Eze 14:8; andthey shall go out from [one] fire, and [another] fire shall devour them: from one calamity to another; those that escaped the famine and pestilence in the city fell by the sword; and those that escaped famine, sword, and pestilence, were carried into captivity, and there passed from one hardship and affliction to another.
The Targum is,"I will execute my vengeance on them, because of the words of the law, which were given out of the midst of fire; they have transgressed, and people who are strong as fire shall consume them.'
'Some, as Abendana observes, interpret the fire, out of which they went, of Sennacherib, out of whose hand the Lord delivered them; and the fire which devoured them, of Nebuchadnezzar king of Babylon; and it may be rendered, "they have gone out" , &c.
and ye shall know that I [am] the Lord, when I set my face against them; he is known by his judgments to be the Lord God omnipotent, holy, just, and true.