For out of the north there cometh up a nation against her,.... The Medes and Persians, which under Cyrus were one nation; and which not only lay north of Judea, where this prophecy came, but of Babylon, against which they were to come; and might lay more north to it, before the enlargement of their dominions; and besides, Cyrus came through Assyria to Babylon, which lay north of it; see Isa 41:25.
Thus, as Rome Pagan was sacked and taken by the Goths and Vandals, that came out of the north; so Rome Papal, and the antichristian states, will be destroyed by the Christian princes of the north, or those who have embraced what the Papists call the northern heresy; tidings out of the north shall trouble antichrist, Da 11:44;which shall make her land desolate, and none shall dwell therein; that is, in process of time; for this desolation was not made at once; it was begun by Cyrus, made greater by Darius, and completed by Seleucus Nicator;they shall remove, they shall depart, both man and beast; or, "from man to beast" ; such as were not slain should either flee away or be carried captive; so that in time none should remain, either of man or beast; see Isa 13:19; and for the accomplishment of it on mystical Babylon see Re 18:2.